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Differences in mammographic density between Asian and Caucasian populations: a comparative analysis

Rajaram, Mariapun, Eriksson, Tapia, Kwan, Ho, Harun, Rahmat, Czene, Taib, Hall, Teo

“Variation in dense volume for post-menopausal Asian and Caucasian women reflects population differences in breast cancer risk, and these are attributed to differences in height, weight, and parity. Further research is needed to identity a suitable mammographic density measure as a biomarker for breast cancer risk among pre-menopausal Asian women.”

Increased peri-ductal collagen micro-organization may contribute to raised mammographic density

McConnell, O'Connell, Brennan, Weiping, Howe, Joseph, Knight, O'Cualain, Lim, Leek, Waddington, Rogan, Astley, Gandhi, Kirwan, Sherratt, Streuli

“These preliminary data suggest that remodelling, and hence stiffening, of the existing stromal collagen microarchitecture promotes high mammographic density within the breast. In turn, this aberrant mechanical environment may trigger neoplasia-associated mechanotransduction pathways within the epithelial cell population”

Association of infertility and fertility treatment with mammographic density in a large screening-based cohort of women: a cross-sectional study

Lundberg, Johansson, Rodroguez-Wallberg, Brand, Czene, Hall, Iliadou

“Women with a history of infertility had higher absolute dense volume than other women. Among the infertile women, those who had gone through COS [controlled ovarian stimulation] had the highest absolute dense volume.”