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Circulating Receptor Activator of Nuclear Factor-κB (RANK), RANK ligand (RANKL) and Mammographic Density in Premenopausal Women

Toriola, Appleton, Zong, Luo, Weilbaecher, Tamimi, Colditz

“These findings support the inhibition of RANKL signaling as a pathway to reduce mammographic density and possibly breast cancer incidence in high-risk women with dense breasts.”

Differential impact of body mass index on absolute and percent breast density: implications regarding their use as breast cancer risk biomarkers

Schetter, Hartman, Liao, Richie, Prokopczyk, DuBrock, Signori, Hamilton, Demers, El-Bayoumy, Manni

“[Absolute breast density (ABD)] corrected by BMI should be the gold standard BD measurement

Mammographic Breast Density and Urbanization: Interactions with BMI, Environmental, Lifestyle, and Other Patient Factors

Perry, Moss, Dixon, Milner, Mokbel, Lemech, Arkenau, Duffy, Pinker

“Urban residence was significantly associated with an increasing percent of MBD … Our results suggest that the association between urban women and increased MBD can be partially explained by their lower BMI, but for women still working, there appear to be other contributing factors.”

Effect of excessive gestational weight on daughters’ breast density at the end of puberty onset

López, Garmendia, Shepherd, Michels, Corvalán, Pereira

“Daughters of women who had EGWG had higher levels of AFGV (OR: 2.02; 95%CI 1.16–3.53) at Tanner B4, which could be explained by metabolic and hormonal exposure in utero.”

Ethnic and age differences in right-left breast asymmetry in a large population-based screening population

Hudson, Wilkinson, Denholm, De Stavola, Dos-Santos-Silva

“Automated measurements from digital raw mammographic images of 54,591 cancer-free participants (aged 47–73) in a UK breast screening programme were used to calculate absolute (cm3) and relative asymmetry in BV and DV … BV and DV absolute asymmetry were positively correlated with the corresponding volumetric dimension
(BV or DV).”

Volumetric Mammographic Density, Age-Related Decline, and Breast Cancer Risk Factors in a National Breast Cancer Screening Program

Vik Hjerkind, Ellingjord-Dale, Johansson, Siv Aase, Roth Hoff, Hofvind, Fagerheim, dos-Santos-Silva, Ursin

“VMD is associated with several breast cancer risk factors, the strongest being BMI, where the direction of the association differ for percent and absolute VMD. The inverse association with age appears modified by menopausal status and other breast cancer risk factors.”

Breast density across a regional screening population: effects of age, ethnicity and deprivation

Heller, Hudson, Wilkinson

“Our mapping of BD in a regional screening programme demonstrates impact of age, ethnicity and socioeconomic status on BD with attendant implications for breast cancer risk.”

Adiposity change over the life course and mammographic breast density in postmenopausal women

Han, Berkey, Herman, Appleton, Alimujiang, Colditz, Toriola

“We used multivariable linear regression models, adjusted for confounders, to investigate the associations of BMI change with volumetric percent density, dense volume, and nondense volume, assessed using Volpara in 367 women.”

Milk intake and mammographic density in premenopausal women

Han, Zong, Li, Colditz, Toriola

“Recent low/reduced-fat milk intake was inversely associated with volumetric percent density in premenopausal women.”

Age and Ethnic Differences in Volumetric Breast Density in New Zealand Women: A Cross-Sectional Study

Ellison-Loschmann, McKenzie, Highnam, Cave, Walker, Jeffreys

“In particular, compared to Pakeha women, Ma¯ori women had higher levels of absolute volumetric density and Asian women had lower levels. For percentage breast density, Asian women had higher and Pacific women had lower breast density.”