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Mammographic density changes during neoadjuvant breast cancer treatment: NeoDense, a prospective study in Sweden

Skarping, Fornvik, Heide-Jørgensen, Sartor, Hall, Zackrisson, Borgquist

“The majority of patients decreased their MD during [neoadjuvant chemotherapy (NACT)]. We found no evidence of MD as a predictive marker of pCR in the neoadjuvant setting.”

Can Dietary and Physical Activity Modifications Reduce Breast Density in Postmenopausal Women? The DAMA Study, a Randomized Intervention Trial in Italy

Masala, Assedi, Sera, Ermini, Occhini, Castaldo, Pierpaoli, Caini, Bendinelli, Ambrogetti, Palli

“This intervention trial suggests that a 24-month dietary or PA intervention may reduce MBD in postmenopausal women.”

Breast tissue density change after oophorectomy in BRCA mutation carrier patients using visual and volumetric analysis

Lecler, Dunant, Delaloge, Wehrer, Moussa, Caron, Balleyguier

“Oophorectomy is associated with a decrease in breast density and younger patients exhibit a larger absolute decrease. Volpara is more sensitive to identify change over time compared to visual assessment.”

Effect of neoadjuvant chemotherapy on breast tissue composition: a longitudinal mammographic study with automated volumetric measurement

Jang, Kim, Chae, Lee, Kim, Lee, Kim

“NAC affects breast tissue composition, reflected as reductions in BV, FGV, and BD. Mammography with automated volumetric measurement can capture quantitative changes in these breast tissue parameters during NAC.”

The impact of bariatric surgery on qualitative and quantitative breast density

Hassinger, Mehaffey, Knisely, Contrella, Brenin, Schroen, Schirmer, Hallowell, Harvey, Showalter

“Increased VBD, decreased FGV, and decreased total breast volume were seen following bariatric surgery-induced weight loss. There was no difference in qualitative breast density, highlighting the discrepancy between BI-RADS and VolparaDensity™ measurements.”

Effect of Bazedoxifene and Conjugated Estrogen (Duavee) on Breast Cancer Risk Biomarkers in High-Risk Women: A Pilot Study

Fabian, Nye, Powers, Nydegger, Kreutzjans, Phillips, Metheny, Winblad, Zalles, Hagan, Goodman, Gajewski, Koestler, Chalise, Kimler

“We found that FGV, a demonstrated risk biomarker, was significantly reduced after 6 months of Duavee in the 26 women with Volpara software assessed mammograms.”

Longitudinal changes in volumetric breast density in healthy women across the menopausal transition

Engmann, Scott, Jensen, Winham, Ma, Brandt, Mahmoudzadeh, Whaley, Hruska, Wu, Norman, Hiatt, Heine, Shepherd, Pankratz, Miglioretti, Kerlikowske, Vachon

“High premenopausal dense volume was a strong predictor of greater reductions in
dense volume across the menopausal transition … We found that few factors other than premenopausal density influence changes in dense volume across the menopausal transition, limiting targeted prevention efforts.”

Longitudinal changes in volumetric breast density with tamoxifen and aromatase inhibitors

Engmann, Scott, Jensen, Ma, Brandt, Mahmoudzadeh, Malkov, Whaley, Hruska, Wu, Winham, Miglioretti, Norman, Heine, Shepherd, Pankratz, Vachon, Kerlikowske

“Automated software can detect volumetric breast density changes among women
on tamoxifen and AI … If declines in volumetric density predict breast cancer outcomes, these measures may be used as interim prognostic indicators.”

Mammographic density change in a cohort of premenopausal women receiving tamoxifen for breast cancer prevention over 5 years

Brentnall, Warren, Harkness, Astley, Wiseman, Fox, Fox, Eriksson, Hall, Cuzick, Evans, Howell.

“All measures showed a consistent and large average tamoxifen-induced change in density over the first year, and a continued decline thereafter.”

The Short-Term Effect of Weight Loss Surgery on Volumetric Breast Density and Fibroglandular Volume

Vohra, Kachare, Vos, Schroeder, Schuth, Suttle, Fitzgerald, Wong, Verbanac

“Breast volume and fibroglandular volume decreased, and VBD increased following WLS (weight loss surgery), with the most significant change observed in postmenopausal women and non-diabetics.”