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Screening performance and populations

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Digital breast tomosynthesis: sensitivity for cancer in younger symptomatic women

Whelehan, Ali, Vinnicombe, Ball, Cox, Farry, Jenkin, Lowry, McIntosh, Nutt, Oeppen, Reilly, Stahnke, Steel, Sim, Warwick, Wilkinson, Zafeiris, Evans

“Where available, DBT merits first-line use in the under 60 age group in symptomatic breast clinics, particularly in women known to have very dense breasts.”

Mammographic Density Distribution of Healthy Taiwanese Women and its Naturally Decreasing Trend with Age

Shia, Wu, Huang, Lin, Chen

“Obtaining an MD distribution model with age improves the understanding of breast density trends and age variations and provides a reference for future studies on associations between MD and cancer risk.”

Volumetric breast density and risk of advanced cancers after a negative screening episode: a cohort study

Puliti, Zappa, Rossi, Pierpaoli, Manneschi, Ambrogetti, Ventura, Mantellini

“BD has a strong impact on the risk of advanced cancers after a negative screening episode, the best early surrogate of BC mortality. Therefore, our results suggest that screening effectiveness is quite different among BD categories.”

Change in mammographic density across birth cohorts of Dutch breast cancer screening participants

Napolitano, Lynge, Lillholm, Vejborg, van Gils, Nielsen, Karssemeijer

“This study based on mammographic density measurements collected over a 13 year period in the Netherlands indicated that density increased over birth cohort in particular for women in their 50s. This could possibly be related to an increasing age of natural menopause, but further longitudinal studies are needed to test this observation.”

Comparing Screening Outcomes for Digital Breast Tomosynthesis and Digital Mammography by Automated Breast Density in a Randomized Controlled Trial: Results from the To-Be Trial

Moshina, Aase, Danielsen, Haldorsen, Lee, Zackrisson, Hofvind

“Screening with digital breast tomosynthesis combined with synthetic two-dimensional mammograms (DBT+SM) versus digital mammography (DM) yielded lower recall rates for women with Volpara Density Grade (VDG) 1 and VDG 2. Adjusted relative risk of recall and screen-detected breast cancer increased with denser breasts for DBT+SM but not for DM.”

Automated Volumetric Analysis of Mammographic Density in a Screening Setting: Worse Outcomes for Women with Dense Breasts

Moshina, Sebuødegård, Lee, Akslen, Tsuruda, Elmore, Hofvind

“Screening examinations of women with dense breasts classified by using automated software resulted in higher recall rate, lower sensitivity, larger tumor diameter, and more lymph node–positive disease compared with women with nondense breasts.”

Performance of a subsidised mammographic screening programme in Malaysia, a middle-income Asian country

Lee, Mariapun, Rajaram, Teo, Yip

“The cancer detection rate is similar to population-based screening mammography programmes in high-income Asian countries. Unlike population-based screening programmes in Caucasian populations where the adjunct ultrasonography rate is 2–4%, we report that 3 out of 10 women attending screening mammography were recommended for adjunct ultrasonography. This could be because Asian women attending screening are likely premenopausal and hence have denser breasts.”

Influence of breast compression pressure on the performance of population-based mammography screening

Holland, Sechopoulos, Mann, den Heeten, van Gils, Karssemeijer

“Percent dense volume increased with increasing pressure, while breast volume decreased … Results suggest that if too much pressure is applied during mammography this may reduce sensitivity. In contrast, if pressure is low this may decrease specificity.”

Volumetric Mammographic Density, Age-Related Decline, and Breast Cancer Risk Factors in a National Breast Cancer Screening Program

Vik Hjerkind, Ellingjord-Dale, Johansson, Siv Aase, Roth Hoff, Hofvind, Fagerheim, dos-Santos-Silva, Ursin

“VMD is associated with several breast cancer risk factors, the strongest being BMI, where the direction of the association differ for percent and absolute VMD. The inverse association with age appears modified by menopausal status and other breast cancer risk factors.”

Breast density across a regional screening population: effects of age, ethnicity and deprivation

Heller, Hudson, Wilkinson

“Our mapping of BD in a regional screening programme demonstrates impact of age, ethnicity and socioeconomic status on BD with attendant implications for breast cancer risk.”

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