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Circulating Receptor Activator of Nuclear Factor-κB (RANK), RANK ligand (RANKL) and Mammographic Density in Premenopausal Women

Toriola, Appleton, Zong, Luo, Weilbaecher, Tamimi, Colditz

“These findings support the inhibition of RANKL signaling as a pathway to reduce mammographic density and possibly breast cancer incidence in high-risk women with dense breasts.”

Quantitative Mammographic Density Measurements and Molecular Subtypes in Chinese Women with Breast Cancer

Tian, Guida, Koka, Li, Zhu, Sung, Chan, Zhang, Tang, Guo, Den, Hu, Lu, Gierach, Li, Yang

“Although biological mechanisms remain to be investigated, the associations for the HER2-enriched and luminal B subtypes with increasing MD may partially explain the higher prevalence of luminal B and HER2+ breast cancers previously reported in Asian women.”

Mammographic density changes during neoadjuvant breast cancer treatment: NeoDense, a prospective study in Sweden

Skarping, Fornvik, Heide-Jørgensen, Sartor, Hall, Zackrisson, Borgquist

“The majority of patients decreased their MD during [neoadjuvant chemotherapy (NACT)]. We found no evidence of MD as a predictive marker of pCR in the neoadjuvant setting.”

Volumetric breast density is essential for predicting cosmetic outcome at the late stage after breast-conserving surgery

Shiina, Sakakibara, Fujisaki, Iwase, Nagashima, Sangai, Kubota, Akita, Takishima, Miyazaki

“To improve the long-term quality of life after [breast-conserving therapy (BCT)] of breast cancer patients, the correlation of volumetric breast density (VBD) and cosmetic outcome at the late stage after BCT was evaluated … A combination of VBD and PBVE could predict cosmetic outcome after BCT and contribute to the selection for the appropriate BCT.”

Mammographic Density Distribution of Healthy Taiwanese Women and its Naturally Decreasing Trend with Age

Shia, Wu, Huang, Lin, Chen

“Obtaining an MD distribution model with age improves the understanding of breast density trends and age variations and provides a reference for future studies on associations between MD and cancer risk.”

Implant volume estimation in direct-to-implant breast reconstruction after nipple-sparing mastectomy

Shia, Yang, Wu, Lai, Huang, Chen

“These implant volume estimate formulas benefit surgeons by providing a preoperative implant volume assessment in DTI reconstruction using the breast volume and an intraoperative assessment using the specimen weight.”

Supplemental Breast Cancer Screening With Molecular Breast Imaging for Women With Dense Breast Tissue

Shermis, Wilson, Doyle, Martin, Merryman, Kudrolli, Brenner

“When incorporated into a community-based clinical practice environment, molecular breast imaging yielded a high incremental cancer detection rate of 7.7% at an acceptable radiation dose. These results show the utility of molecular breast imaging as a
supplementary screening tool to mammography for women with dense breasts.”

Mechanical standardisation of mammographic compression using Volpara software

Serwan, Matthews, Davies, Chau

“Real-time compression pressure standardisation may benefit examination consistency. The relationship between breast volume, contact area, compression force and resultant compression pressure may aid in developing an objective compression protocol for clinical practice.”

Differential impact of body mass index on absolute and percent breast density: implications regarding their use as breast cancer risk biomarkers

Schetter, Hartman, Liao, Richie, Prokopczyk, DuBrock, Signori, Hamilton, Demers, El-Bayoumy, Manni

“[Absolute breast density (ABD)] corrected by BMI should be the gold standard BD measurement

Digital volumetric measurement of mammographic density and the risk of overlooking cancer in Japanese women

Sawada, Akashi, Nakamura, Kuwayama, Enokido, Yoshida, Hashimoto, Ide, Masuda, Taruno, Oyama, Takamaru, Kanada, Ikeda, Kosugi, Sato, Nakayama, Ata, Tonouchi, Sakai, Matsunaga, Matsutani

“The proportions of Japanese women with dense breasts were high. In addition, the false-negative rate for women with dense breasts was also high. Owing to this, Japanese women with dense breasts may need to commonly undergo additional tests to ensure detection of breast cancer in the screening MMG.”